کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
744052 1462126 2008 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
A gramicidin analogue that exhibits redox potential-dependent cation influx
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آنالیزی یا شیمی تجزیه
پیش نمایش صفحه اول مقاله
A gramicidin analogue that exhibits redox potential-dependent cation influx
چکیده انگلیسی

A synthetic analogue of gramicidin A, gram-2-(nicotinamidyl)ethyl carbamate (gAN) was found to regulate the influx of potassium ions depending on its redox state. At potentials less than −0.52 (±0.05) V, the nicotinamide group in gAN is reduced and allows charge- and size-selective influx of cations. In the oxidised state, charge repulsion between the positively charged nicotinamide group and the cations prevents any influx of cations. Chronoamperometric experiments were conducted to determine permeabilities of Eu3+, Tl+, K+ ions in a BLM porated with gAN. Scanning electrochemical microscopy (SECM) experiments were conducted with two ions: permeant K+ ions and the larger (CH3)4N+ ion which blocks the channel. The switching potential for gAN, at which the channel allows flux monovalent cations, is shown to be potential and pH-dependent and temperature-independent.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Sensors and Actuators B: Chemical - Volume 130, Issue 2, 28 March 2008, Pages 630–637
نویسندگان
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