کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
745828 | 894433 | 2008 | 8 صفحه PDF | دانلود رایگان |
A DNA sequencing device which integrates transverse conducting electrodes for the measurement of electrode currents during DNA translocation through a nanopore has been nanofabricated and characterized. A focused electron beam (FEB) milling technique, capable of creating features on the order of 1 nm in diameter, was used to create the nanopore. The device was characterized electrically using gold nanoparticles as an artificial analyte with both DC and AC measurement methods. Single nanoparticle/electrode interaction events were recorded. A low-noise, high-speed transimpedance current amplifier for the detection of nano- to picoampere currents at microsecond time scales was designed, fabricated and tested for future integration with the nanopore device.
Journal: Sensors and Actuators B: Chemical - Volume 132, Issue 2, 16 June 2008, Pages 593–600