Rapid sensing of hepatitis B virus using QCM in the thickness shear mode

It is shown that sensor for hepatitis can be manufactured using a thickness shear mode resonator. Not the added mass is measured but the moment of particle (virus) detachment from the QCM surface is detected, which explains the high sensitivity of this sensor. The sensor allows confident determination of the presence of 140–150 viruses, while a typical signal shape is an additional warranty of selectivity confirming that it is hepatitis B virus (HBV) that was fixed on the surface. This method can be the ground for a prototype of the sensor for rapid analysis based on affine interactions.