کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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751030 | 895188 | 2011 | 9 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Amperometric determination of l-dopa by nickel hexacyanoferrate film modified gold nanoparticle graphite composite electrode Amperometric determination of l-dopa by nickel hexacyanoferrate film modified gold nanoparticle graphite composite electrode](/preview/png/751030.png)
Surface modification of graphite electrode with nickel hexacyanoferrate (NiHCF) film through 2-mercaptoethylamine (MEA) capped gold nanoparticle (GNP) was achieved by a novel fabrication approach. The NiHCF modified electrode exhibits a distinct pair of redox peaks corresponding to anodic and cathodic reactions of hexacyanoferrate (II/III) of NiHCF with a formal potential of 0.33 V versus SCE. l-Dopa, is a potential chemotherapeutic drug used for the treatment of a neurodegenerative disease like Parkinson's disease (PD). l-Dopa was successfully determined by NiHCF modified electrode in the concentration range of 0.82 μM to 2.5 mM with a good sensitivity of 0.363 μA/μM. A reduction in overpotential of 200 mV with a detection limit of 0.53 μM was obtained. Determination of l-dopa in commercial tablets was also investigated by the proposed sensor.
Journal: Sensors and Actuators B: Chemical - Volume 156, Issue 2, August 2011, Pages 606–614