Hydrophilic modified magnetic multi-walled carbon nanotube for dispersive solid/liquid phase microextraction of sunitinib in human samples

In this paper, a novel approach for the efficient microextraction and determination of anticancer drug, sunitinib from human samples is described. We synthesized a new nanocomposite; honey coated magnetic multi-walled carbon nanotubes (Honey@magnetic-CNTs). This nanocomposite retains the magnetic properties of individual magnetic nanoparticles (MNPs) and can be effectively separated under an external magnetic field. The synthesized nanoparticles were characterized by FT-IR, VSM, EDAX and XRD and TEM studies. The spherical particles obtained before and after the functionalization had sizes of 14 nm and 16 nm, respectively. The method is based on Honey@magnetic-CNTs assisted dispersive solid-liquid phase microextraction for determination and analysis of the drug. The influences of experimental parameters were investigated. Under optimal conditions, the applied nanocomposite showed good performance, high sensitivity and fast extraction of the analyte from biological samples. In linearity test, the regression correlation coefficient was obtained more than 99% for analyte of interest and linear dynamic range for the proposed method was from 5 to 5000 ng mL−1. Method detection and quantification limits were 1.58 ng mL−1 and 5.28 ng mL−1, respectively. Relative standard deviation was 3.15%.