The alteration of H4-K16ac and H3-K27met influences the differentiation of neural stem cells

The simplified workflow and results of this study. Rat NSCs was induced to differentiate to early-stage neurons. We identified the alteration of various modifications on histone H4 and H3.1 and found that the up-regulation of H4-K16ac coupled with the down-regulation of H3-K27met would significantly inhibit the NSCs differentiation.260