Protein profiling of mefloquine resistant Plasmodium falciparum using mass spectrometry-based proteomics

- We studied protein expression in mefloquine-sensitive and -resistant P. falciparum.
- Congenic mefloquine-sensitive and -resistant Thai TM036 lines were used.
- The protein profiles of both lines were determined by GeLC-MS/MS-based proteomics.
- The mefloquine-treated resistant line had 36 up- and 34 down-regulated proteins.
- The functions of the proteins identified herein warrant further investigation.