Negative ion laser ablation glow discharge-time of flight mass spectrometry of organic molecules

► Negative ion (NI) measurements of some organic compounds. ► Measurements first done by laser ablation coupled to pulsed glow discharge TOF-MS. ► Measurements then performed by MALDI TOF-MS. ► NI measurements provide complementary info to positive ion mode in both techniques. ► Ionization in NI mode of this new technique less matrix dependent than in MALDI.