Demonstration of on-line desalination for LC-MS using phosphate adsorption onto TiO2-coated magnetic microparticles within a microchannel

► The desalination interface device (DID) for LC-MS was developed. ► Phosphate was adsorbed onto TiO2-coated magnetic microparticles. ► The S/N ratio in the mass spectra of reserpine was increased 5.3-fold by LC-DID-MS.