کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
7638843 1494808 2018 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Comparison of the effect of dietary copper nanoparticles and one copper (II) salt on the metabolic and immune status in a rat model
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آنالیزی یا شیمی تجزیه
پیش نمایش صفحه اول مقاله
Comparison of the effect of dietary copper nanoparticles and one copper (II) salt on the metabolic and immune status in a rat model
چکیده انگلیسی
The aim of the study was to evaluate the effects of a diet containing different levels of Cu in two different chemical forms (carbonate and nanoparticles) on metabolic, immune and antioxidant status in a rat model. Five experimental treatments (8 rats in each) were used to test different dosages of Cu added to the diet (standard −6.5 mg/kg, half the standard dosage −3.25 mg/kg, and no added Cu as a negative control) and two sources of added copper (standard −CuCO3 and copper nanoparticles −CuNPs). Blood and urine samples were collected from all the animals after four weeks of treatment. Metabolic and immune parameters were determined in blood and urine samples. The study has shown that a dietary Cu deficiency (negative control) decreases rat's plasma levels of Cu, Fe, CREAT, BIL and IL-6, whereas reducing the level of Cu from the recommended 6.5 mg/kg to 3.25 mg/kg decreases only the plasma concentration of TG, IgE and IL-6. Replacing CuCO3 with CuNPs in rat diets affects their metabolism, as indicated by decreased Ca, CREAT, BIL, ALB and IL-6 plasma levels. To sum up, CuNP added to a diet of rats have a more beneficial effect on metabolic indices (indicative of kidney and liver function) and inhibit inflammatory processes more effectively than CuCO3.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Trace Elements in Medicine and Biology - Volume 48, July 2018, Pages 111-117
نویسندگان
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