کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
7639343 | 1494820 | 2016 | 24 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
The influence of manganese treatment on the distribution of metal elements in rats and the protection by sodium para-amino salicylic acid
ترجمه فارسی عنوان
تاثیر درمان منگنز بر توزیع عناصر فلزی در موش صحرایی و حفاظت از پارامیای آمنیال سلیسیلیک اسید
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موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آنالیزی یا شیمی تجزیه
چکیده انگلیسی
Manganese (Mn) overexposure induced neurological damages, which could be potentially protected by sodium para-aminosalicylic acid (PAS-Na). In this study, we systematically detected the changes of divalent metal elements in most of the organs and analyzed the distribution of the metals in Mn-exposed rats and the protection by PAS-Na. Sprague Dawley (SD) rats received intraperitoneal injections of 15 mg/kg MnCl2·4H2O (5 d/week for 3 weeks), followed by subcutaneous (back) injections of PAS-Na (100 and 200 mg/kg, everyday for 5 weeks). The concentrations of Mn and other metal elements [Iron (Fe), Copper (Cu), Zinc (Zn), Magnesium (Mg), Calcium (Ca)] in major organs (liver, spleen, kidney, thighbone and iliac bone, cerebral cortex, hippocampus and testes) and blood by Inductively Coupled Plasma-Atomic Emission Spectrometry (ICP-AES). The results showed that Mn overexposure significantly increased Mn in most organs, Fe and Zn in liver, Fe and Mg in blood; however decreased Fe, Cu, Zn, Mg and Ca in cortex, Cu and Zn in kidney, Cu and Mg in iliac bone, and Zn in blood. In contrast, PAS-Na treatment restored most changes particularly in cortex. In conclusion, excessive Mn exposure disturbed the balance of other metal elements but PAS-Na post-treatments could restore these alterations.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Trace Elements in Medicine and Biology - Volume 36, July 2016, Pages 84-89
Journal: Journal of Trace Elements in Medicine and Biology - Volume 36, July 2016, Pages 84-89
نویسندگان
Zong-Xiang Yuan, Hai-Bin Chen, Shao-Jun Li, Xiao-Wei Huang, Yu-Huan Mo, Yi-Ni Luo, Sheng-Nan He, Xiang-Fa Deng, Guo-Dong Lu, Yue-Ming Jiang,