Synthesis and characterization of PEGylated dendrimers based on magnetic nanoparticles for letrozole extraction and determination in body fluids and pharmaceutical samples

In this paper, we aimed to develop magnetic nanoparticles (MNPs) conjugated ten generation oxime dendrimer terminated with polyethylene glycol as the drug extractant for letrozole and some affecting parameters in this process like contact time, pH and reusability, were also optimized. The PEGylated dendrimer-based MNPs/SiO2 were characterized in details by Fourier transform infrared spectroscopy, field emission scanning electron microscopy, thermogravimetric analysis and vibration sample magnetometer. The range of particle size of the compound was 10 to 70 nm. The magnetic nanoparticles were mesoporous and superparamagnetic and therefore, researched for their possible use in the extraction of a cancer drug, letrozole. It can be expected that this nano-sorbent has the potential to be applied for separation and determination of letrozole in biological fluids and pharmaceutical samples, due to its high yield and cycling stability.