کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
7643108 | 1494878 | 2014 | 21 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Improving the performance of narrow-bore HPLC columns using active flow technology
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آنالیزی یا شیمی تجزیه
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Active flow technology (AFT) columns are designed to remove inefficient flow processes associated with the column wall and radial heterogeneity. This study is the first to explore AFT on a 2.1 mm internal diameter (i.d.) column, emulating a 1.0 mm i.d. column. The performance of the AFT column was compared to a conventional 1.0 mm i.d. column; at the highest linear velocities tested it was observed that the AFT column functioning as a virtual 1.0 mm i.d. column had an efficiency gain that was 58% compared to the conventional 1 mm i.d. column. The performance of the AFT column was also compared to a conventional column of the same physical dimensions and smaller particles; at the highest velocity tested for the conventional 3 μm column, the AFT virtual 1.0 mm i.d. column had a 20% efficiency with half of the backpressure. These comparative gains in efficiency at high flow rates demonstrate the advantage of using AFT 2.1 mm i.d. columns with a virtual 1 mm i.d., for high throughput analyses and low volume detection methods; additionally, a sensitivity gain of 45% was observed.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Microchemical Journal - Volume 116, September 2014, Pages 230-234
Journal: Microchemical Journal - Volume 116, September 2014, Pages 230-234
نویسندگان
Arianne Soliven, Dominic Foley, Luisa Pereira, Stanly Hua, Tony Edge, Harald Ritchie, Gary R. Dennis, R. Andrew Shalliker,