Determination of selenium compounds in food supplements using reversed-phase liquid chromatography-inductively coupled plasma mass spectrometry

► Selenium compounds in food supplements were determined using HLPC-ICP-MS. ► Ar dimer ion interferences on Se determination were suppressed with CH4 as the DRC reaction gas. ► Selenium species were quantitatively extracted using microwave heating. ► γ-Glutamyl-methyl-Se-cysteine was identified in Selenium Tablet using ESI-MS/MS.