Stationary phases based on poly(methyloctadecylsiloxane) thermally immobilized onto titanized silica for high-performance liquid chromatography

► HPLC support prepared by titanization of silica. ► Stationary phase prepared by thermal immobilization of PMODS onto the support. ► Optimization of preparation by central composite design. ► Evaluation of the stationary phase with several standardized test mixtures. ► Potential applications for separation of polycyclic aromatic hydrocarbons and psychotropic drugs.