Gold glyconanoparticle-based colorimetric bioassay for the determination of glucose in human serum

► Mannose-stabilized gold nanoparticles have been used for colorimetric bioassay. ► The addition of Con A induces the aggregation of gold nanoparticles. ► Glucose hinders the Con A-induced aggregation of gold nanoparticles. ► It results in the decrease of surface plasmon absorption band shift. ► The simple method provides a sensitive assay for glucose in human serum samples.