Antibacterial, in vitro antitumor activity and structural studies of rhodium and iridium complexes featuring the two positional isomers of pyridine carbaldehyde picolinic hydrazone ligand

Reaction of rhodium and iridium precursor compounds with ligand L1 in 1:2 and 1:1 metal dimer to ligand ratio has yielded mononuclear and dinuclear complexes respectively. In contrast, ligand L2 has yielded dinuclear metalla-macrocyclic complexes irrespective of the ratios. Complexes 1 and 2 are more cytotoxic against Dalton's ascites lymphoma (DL) cells and comparatively less toxic on normal cells. Complexes 1, 2, 5 and 6 are considerably bactericidal against the two species considered viz., Proteus vulgaris and Vibrio parahaemolyticus.106