کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
7695935 | 1496515 | 2017 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
HPLC method development, validation and its application to investigate in vitro effect of pioglitazone on the availability of H1 receptor antagonists
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی (عمومی)
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: HPLC method development, validation and its application to investigate in vitro effect of pioglitazone on the availability of H1 receptor antagonists HPLC method development, validation and its application to investigate in vitro effect of pioglitazone on the availability of H1 receptor antagonists](/preview/png/7695935.png)
چکیده انگلیسی
The method has been developed and validated for the simultaneous determination of pioglitazone and H1-receptor antagonists (fexofenadine, cetirizine and levocetirizine) in formulations and human serum. Utilizing HPLC techniques, an assay was designed to determine the in vitro effects of pioglitazone on H1-receptor antagonists. Obtained results were verified using the UV spectrophotometric technique. First-derivative values versus concentrations were used to plot calibration curves of these drugs and were found to similar with the HPLC data. The availability of pioglitazone remained unchanged in absence or presence of fexofenadine, cetirizine and levocetirizine. This in vitro analysis confirms the harmless co-administration of pioglitazone and H1-receptor antagonists, and can serve as the foundation for designing further in vivo studies.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of the Association of Arab Universities for Basic and Applied Sciences - Volume 22, February 2017, Pages 70-75
Journal: Journal of the Association of Arab Universities for Basic and Applied Sciences - Volume 22, February 2017, Pages 70-75
نویسندگان
Agha Zeeshan Mirza, M. Saeed Arayne, Najma Sultana,