کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
7697236 | 1496545 | 2017 | 25 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Neurotoxicity and brain localization of europium doped Gd2O3 nanotubes in rats after intranasal instillation
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی (عمومی)
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Neurotoxicity and brain localization of europium doped Gd2O3 nanotubes in rats after intranasal instillation Neurotoxicity and brain localization of europium doped Gd2O3 nanotubes in rats after intranasal instillation](/preview/png/7697236.png)
چکیده انگلیسی
Europium doped Gd2O3 nanotubes (Gd2O3:Eu3+ NTs) were synthesized and characterized. Then, the neurotoxicity and brain localization of Gd2O3:Eu3+ NTs were evaluated. All experimental rats were administered by intranasal instillation with 30 μL Gd2O3:Eu3+ NTs suspension 3.0 and 15.0 mg/mL respectively every other day for 35 consecutive days, and the rats of control group were administered with an equal volume of physiological saline. The Morris water maze was used to assess the rats' spatial learning and memory ability. The oxidative stress-related biomarkers and the activity of AChE in striatum and hippocampus were analyzed, and the histopathology of hippocampus and striatum was observed. The brain localization of gadolinium (Gd) was measured. The results showed that the escape latency of the rats in high-dose group prolonged significantly compared with that of control group after treatment of six weeks (p < 0.05), and the swimming time in D quadrant of high-dose group shortened significantly compared with the control group (p < 0.01). In addition, high-dose Gd2O3:Eu3+ NTs could decrease the activity of GSH-Px and CAT in hippocampus and the activity of SOD in striatum (p < 0.05). MDA content in hippocampus and striatum of high-dose group increased (p < 0.05). High dose Gd2O3:Eu3+ NTs could increase the activity of AChE in hippocampus (p < 0.05) and in striatum (p < 0.001). But there were no significant differences between the low-dose group and control group (p > 0.05). The results of Gd localization in brain showed that the ranking of Gd levels was olfactory bulb > striatum > hippocampus > cerebellum > brain stem > frontal cortex. The pathology results indicated that high dose Gd2O3:Eu3+ NTs resulted in degeneration necrosis, nucleus pycnosis, and axons disappearance of the nerve cells at CA1, CA3 and DG area of hippocampus. Therefore, the results implied that Gd2O3:Eu3+ NTs have the potential neurotoxicity and a possible danger in causing neurodegenerative disorders after intranasal instillation.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Rare Earths - Volume 35, Issue 11, November 2017, Pages 1126-1132
Journal: Journal of Rare Earths - Volume 35, Issue 11, November 2017, Pages 1126-1132
نویسندگان
Huifang Liu, Wencong Zhao, Xiaochun Wang, Guang Jia, Yi Jin, Kun Ge, Huanyun Ma, Jinchao Zhang,