The coupling frequency of bioliquid-filled microtubules considering small scale effects

This paper presents an investigation on the effects of bioliquid density and the constrained stiffness of surrounding bio-medium on the coupling frequency characteristics of bioliquid-filled microtubules. Here, the nonlocal elastic theory is utilized to describe the nano-scale effect of the microtubule. Results show that the influence of small scale on the coupled vibration frequency of bioliquid-filled microtubules embedded in bio-medium gradually increases when the bioliquid density in microtubules is larger than the density of the microtubules. The new investigation results may be used as a useful reference for the ultrasonic examine of microtubule organization and some biomedical clinical applications.

► The influence of scale effect on the frequency of bioliquid-filled MT is described.
► The effect of bio-medium on the frequency is dependent on the bioliquid density.
► The scale effect makes the first order frequency of bioliquid-filled MT increases.