Synthesis and relaxation properties of two non-ion complexes of gadolinium(III) and manganese(II) with derivatives from diethylene triamine pentaacetic acid and isoniazid

Two novel ligands have been synthesized from diethylene triamine pentaacetic acid and isoniazid in different conditions. Their non-ion complexes are synthesized, and relaxivity of complexes are determined. The relaxivity of complexes are larger than that of Gd(DTPA)2−. The results showed that two non-ion complexes are prospective MRI contrast agents.