One-pot asymmetric reductive amination of ketones induced by polyfluoroalkanesulfinamide

A highly diastereoselective reductive amination of ketones using 2-chloro-1,1,2,2-tetrafluoroethane-1-sulfinamide as auxiliary was developed. Both aromatic and aliphatic ketones reacted well under the reaction conditions, giving the corresponding amination products in good yields with excellent diastereoselectivities.