Construction of chiral trifluoromethylated materials by combination of stereochemically predictable SN2′ reaction and Ireland-Claisen rearrangement

► Efficient control of three successive stereocenters by combination of copper-mediated SN2′ reaction and Ireland-Claisen rearrangement. ► Convenient stereodivergent construction of the final products. ► Construction of the product stereochemistry in a predictable fashion.