Pyrazole-type cannabinoid ligands conjugated with fluoro-deoxy-carbohydrates as potential PET-imaging agents: Synthesis and CB1/CB2 receptor affinity evaluation

Novel CB1 ligands were synthesized in good yields via oxime-bioconjugation with fluoro-deoxy-carbohydrates. The compounds showed high nanomolar CB1 receptor affinities and low selectivities vs. the CB2.