Aspect of adhesives in transdermal drug delivery systems

Transdermal drug delivery systems (TDDS), also well-known as “patches,” are the dosage forms designed to deliver a therapeutically effective amount of drug across the skin. The quality attribute of the adhesives in TDDS is indispensible for fabrication design and important to the safety, efficacy and quality evaluation of the final product. Advances in the field of adhesive science have paved the way for designing TDDS that have considerable flexibility. This review article provides a brief idea of adhesives being used in commercially, types of transdermals, their anatomy, fabrication design, assessment of adhesion parameters, regulatory aspects, success and commercial application of adhesive technology in transdermal therapy. This article also provides a framework for past, present and future developments of adhesive based technology in transdermal performance.