Novel tetrahydrocarbazole benzyl pyridine hybrids as potent and selective butryl cholinesterase inhibitors with neuroprotective and β-secretase inhibition activities

A series of dual binding site BuChE inhibitors were designed and synthesized based on 2,3,4,9-tetrahydro-1H-carbazole attached benzyl pyridine moieties. The most potent BuChE inhibitor was compound 6i (IC50 = 0.088 μM). In addition, compound 6i demonstrated neuroprotective and β-secretase inhibition activities.223