Design, synthesis and in vitro evaluation of heterobivalent peptidic radioligands targeting both GRP- and VPAC1-Receptors concomitantly overexpressed on various malignancies - Is the concept feasible?

Targeting malignancies: The heterodimerization of GRPR- and VPAC1R-affine peptides yields bispecific peptidic ligands being able to synergistically target tumor cells overexpressing one or both of these receptors.134