New 6-amino-pyrido[2,3-d]pyrimidine-2,4-diones as novel agents to treat type 2 diabetes: A simple and efficient synthesis, α-glucosidase inhibition, molecular modeling and kinetic study

A novel series of 6-amino-pyrido[2,3-d]pyrimidine-2,4-dione derivatives 3a-s were synthesized and evaluated as new inhibitors for α-glucosidase. All synthesized compounds were superior to standard drug (acarbose). Particularly, compound 3o was around 10-fold more potent than standard drug. The kinetic analysis of the compound 3o revealed that this compound inhibited α-glucosidase in a competitive manner (Ki = 69.2 μM). Docking studies of the most active compounds 3o, 3i, 3e, and 3m were also performed.112