Discovery of novel pyrrolo-pyridine/pyrimidine derivatives bearing pyridazinone moiety as c-Met kinase inhibitors

251Eight series of pyrrolo[2,3-b]pyridine and pyrrolo[2, 3-d]pyrimidine derivatives bearing pyridazinone moiety were designed, synthesized. Moreover, antitumor activity, enzyme-based selectivity, AO staining, Annexin V/PI staining and docking study were carried out.