Synthesis, biological evaluation and molecular modeling study of thiadiazolo[3,2-a][1,3]diazepine analogues of HIE-124 as a new class of short acting hypnotics

Structure of the most active short acting hypnotic GS-62 (33), onset time 6.4 ± 0.2 min, duration of sleep 94.8 ± 5.3 min, and therapeutic index, 6.62.88