Stabilization of c-myc G-Quadruplex DNA, inhibition of telomerase activity, disruption of mitochondrial functions and tumor cell apoptosis by platinum(II) complex with 9-amino-oxoisoaporphine

Platinum complex with 9-amino-oxoisoaporphine is more selective to Hep-G2 cells versus HL-7702 cells, and its cytotoxicity mainly via inhibiting telomerase by interaction with c-myc quadruplex and disruption of mitochondrial function.207