Multi-targeting exploration of new 2-aminothiazolyl quinolones: Synthesis, antimicrobial evaluation, interaction with DNA, combination with topoisomerase IV and penetrability into cells

Potentially multi-targeting new 2-aminothiazolyl quinolones were developed and screened for their antimicrobial activities. Time-kill kinetic assay and antibacterial resistance development were investigated. Membrane permeabilization and DNA interaction were explored for the possible antibacterial mechanism.315