Synthesis and antiproliferative mechanism of action of pyrrolo[3′,2′:6,7] cyclohepta[1,2-d]pyrimidin-2-amines as singlet oxygen photosensitizers

The most potent compound 9g shows absorbance in the near UV-Vis, a detectable activity as 1O2 sensitizer and photoinduced apoptosis with massive production of large amounts of ROS, and a deep involvement of mitochondria and lysosomes.74