Synthesis and biological properties of polyamine modified flavonoids as hepatocellular carcinoma inhibitors

Six novel flavonoid-polyamine conjugates with naphthalene motif were synthesized. Compound 8a displayed favorable selectivity between HepG2 and QSG7701 cells. The combination of 8a with Aspirin generated better additive anti-metastasis effects in vivo, and no weight loss in the treated mice.279