Design and synthesis of some novel 4-Chloro-N-(4-(1-(2-(2-cyanoacetyl)hydrazono)ethyl)phenyl) benzenesulfonamide derivatives as anticancer and radiosensitizing agents

Novel series of sulfonamide derivatives bearing a biologically active hydrazone or pyridone moiety were synthesized. The most potent compounds in this study 4, 10 and 12 were evaluated for their radiosensitizing activity.125