Synthesis, characterization, hypoglycemic and aldose reductase inhibition activity of arylsulfonylspiro[fluorene-9,5′-imidazolidine]-2′,4′-diones

Three of the synthesized sulfonyclyclic urea derivatives were found more potent in-vivo hypoglycemic agents than glibenclamide. In in-vitro ARI assay, the compounds 3a-g were found more ACR1 inhibitors than the standard.