Synthesis, antimalarial and antitubercular activities of meridianin derivatives

A meridianin sulfonamide derivative 14v showed promising antimalarial activity against D2 and W2 strains of Plasmodium falciparum, better than its parent natural product. The C-ring modified analog 12 exhibited potent anti-tubercular activity against sensitive as well as resistant Mtb strains with MIC of 2-8 μg/ml.