Design, synthesis and anticholinesterase activity of novel benzylidenechroman-4-ones bearing cyclic amine side chain

A series of AChE/BuChE inhibitors namely 3-(4-(aminoalkoxy)benzylidene)-chroman-4-ones 7a-r were synthesized as homoisoflavonoid analogs. The obtained results revealed that compounds bearing piperidinylethoxy residue showed potent activity against AChE at sub-micromolar level.