Discovery of N-benzoxazol-5-yl-pyrazole-4-carboxamides as nanomolar SQR inhibitors

A series of N-benzooxazol-5-yl-pyrazole-4-carboxamides were designed and synthesized as potent SQR inhibitors. One candidate (Ki = 11 nM) was successfully identified as the most potent synthetic SQR inhibitor so far.