Novel styryl-indoles as small molecule inhibitors of 25-hydroxyvitamin D-24-hydroxylase (CYP24A1): Synthesis and biological evaluation

A series of imidazole styrylindoles and sulfonyl styrylindoles derivatives were prepared and evaluated for their binding affinity and inhibitory activity against CYP24A1 with molecular modelling studies to determine key binding interactions within the CYP24A1 active site.