Design, synthesis, biological evaluation, and comparative docking study of 1,2,4-triazolones as CB1 receptor selective antagonists

Pharmacophore-oriented 1,2,4-triazolones were designed and synthesized to have CB1 receptor antagonistic potency. Docking simulations were performed to predict the interaction modes of 1,2,4-triazolones binding to both CB1 and CB2 receptors.