Design, synthesis, biological evaluation and docking study of 5-oxo-4,5-dihydropyrano[3,2-c]chromene derivatives as acetylcholinesterase and butyrylcholinesterase inhibitors

A series of fused coumarins bearing N-benzylpyridinium scaffold were designed as AChE and BuChE inhibitors. The 1-(4-fluorobenzyl)pyridinium derivative 6g showed the most potent anti-AChE activity and the highest AChE/BuChE selectivity.