New platinum(II) complexes conjugated at position 7α of 17β-acetyl-testosterone as new combi-molecules against prostate cancer: Design, synthesis, structure-activity relationships and biological evaluation

17β-Acetyl-testosterone-7α-platinum(II) complexes (compounds 10a and f) are new combi-molecules arresting the cell cycle progression in S-phase, inducing γH2AX and exhibiting antitumor activity in the CAM assay.