Glycosylation enhances the anti-migratory activities of isomalyngamide A analogs

Three glycosylated isomalyngamide A analogs 4-6 were prepared. Glycosides 4 and 5 suppress metastasis in MDA-MB-231 cells by inactivating the expression of p-FAK and paxillin through the integrin-mediated antimetastatic pathway.