Synthesis and receptor binding studies of novel 4,4-disubstituted arylalkyl/arylalkylsulfonyl piperazine and piperidine-based derivatives as a new class of σ1 ligands

A novel class of sigma-1 receptor ligands was formed by replacement of methylene group of N-arylalkyl-4-benzylpiperazine or piperidine derivatives with sulfonyl group.