Novel pyrimidopyrimidine derivatives for inhibition of cellular proliferation and motility induced by h-prune in breast cancer

► Synthesis of new pyrimido[5,4-d]pyrimidine compounds. ► Identification of pyrimidopyrimidine compounds specific towards h-prune c-AMP phosphodiesterase activity. ► Characterization of their ability to impair cell proliferation. ► Characterization of their ability to impair cell motility.