Synthesis and antidepressant activity of arylalkanol-piperidine derivatives as triple reuptake inhibitors

► A series of arylalkanol-piperidine derivatives (2a-y) were synthesized. ► Synthesized compounds were tested for triple reuptake inhibition and antidepressant activities. ► 5 compounds exhibited high potency for 5-HT, NA and DA transporters. ► Some compounds showed antidepressant activities in TST and displayed desirable pharmacokinetic properties.