Synthesis of friedelan triterpenoid analogs with DNA topoisomerase IIα inhibitory activity and their molecular docking studies

► Very first report of toisomerase inhibitory activity of the friedelan derivatives. ► 3D molecular docking on topoisomerase IIα (1 bgw, PDB). ► Prediction of nature of interactions of the drug molecules with enzyme. ► Helpful for drug designing and mechanism of drug resistance phenomena. ► Prediction of dose dependent inhibition activity against topoisomerase IIα.