The effect of PLC-γ2 inhibitors on the growth of human tumour cells

► A host of known PLC-γ2 inhibitors were tested against the NCI60 tumour cell panel. ► A class of thieno[2,3-b]pyridines showed excellent growth arrest. ► Derivative 3 gave GI50 = 58 nM for the MDA-MB-435 cell line. ► Haematopoietic cells were restricted by GI50 = 275 nM indicating interaction to PLC-γ2.