One-pot synthesis of novel isoindoline-1,3-dione derivatives bearing 1,2,4-triazole moiety and their preliminary biological evaluation

► 38 Novel isoindoline-1,3-diones were synthesized via a one-pot reaction. ► Antifungal and cytotoxic activities of these compounds were evaluated. ► Antifungal studies of the novel compounds showed promising activity. ► Three compounds displayed much stronger antitumor activity than Fluorouracil.